The removal of a tick alone does not warrant medical treatment with antibiotics. Look for the development of a red rash, which may be an early symptom of Lyme disease. Such a rash, called erythema migrans, often starts as a flat or raised red area and slowly expands over several days. It may have a partial central clearing. Be aware, however, that not all infected individuals develop a rash. Other symptoms may include fatigue, headache, neck stiffness, pain or stiffness in muscles or joints, slight fever, swollen glands, or conjunctivitis. If you have a tick bite followed by a rash or any of these other symptoms, consult your physician.